External links

Share this page:
Other services (opens in new window)
Sets a cookie

Length of pregnancy influenced by placenta structure

Visit Durham University website

17 November 2010

The nine-month pregnancy in humans is influenced by the structure of the placenta, according to new research into the evolution of reproduction in mammals which ends a 100-year mystery.

The study, by Durham and Reading universities was funded by BBSRC, the Natural Environment Research Council (NERC) and the Leverhulme Trust. It shows that babies grow twice as fast in the wombs of some mammals compared to others - a difference that has arisen through evolution of species. The difference in growth rates appears to be due to the structure of the placenta and the way it connects mother and baby.

The research has found that the more intimate the connection is between the tissues of the mother and the foetus, the faster the growth of the baby and the shorter the pregnancy. The findings help to explain why humans, whose placentas do not form the complex web-like structure seen in animals such as dogs and leopards, have relatively lengthy pregnancies.

The structure of the placenta is surprisingly different amongst mammal species although it serves the same basic function in all of them. The scientists say that, despite speculation, the reasons for this variation have been a mystery for more than 100 years, until now.

The researchers, whose findings are published in the academic journal American Naturalist this week, analysed data on 109 mammal species showing for the first time that the structure of the placenta influences pregnancy duration in mammals. The scientists say that the placenta in some mammals is highly 'folded' creating a larger surface area, increasing the rate at which nutrients are passed from mother to baby.

This sort of folding is a common way in which evolution has solved the problem of increasing surface area in animal bodies. It is seen in many tissues where a large surface area needs to be packed into a small space, including the lungs, intestines and cortex of the brain.

Females of all mammal species develop placentas when they conceive, including bats, whales, and elephants. The placenta connects the developing foetus to the lining of the womb to allow nutrient uptake, waste elimination, and gas exchange via the mother's blood supply.

The research team studied the length of pregnancy, structure of placenta, and size of offspring in mammals, and examined how these characteristics have changed during the evolution of mammals. They found that, despite the placenta essentially having the same function in all mammals, there were some striking structural differences.

Previously, the extent to which there is direct contact between the mother's blood and the placenta was thought to reflect an evolutionary arms-race between mother and baby with both battling for 'control' over how much food is given and received. In this conflict, it is believed that the mother needs to reserve some of her resources for her other offspring but the foetus 'demands' more to fuel its growth.

Lead author, Dr Isabella Capellini, says "This study shows that it is not necessarily the contact with maternal blood which determines speed of growth, but the extent to which the tissues of mother and baby are "interlocked", or folded, with one another.

"In humans, the placenta has simple finger-like branches with a relatively limited connection between the mother's tissues and those of the foetus, whereas in leopards, for example, it forms a complex web of interconnections that create a larger surface area for the exchange of nutrients."

Co-author Professor Robert Barton from Durham University explained: "Parent-offspring conflict is universal. From the moment of conception, the physiologies of mother and baby are adapted to achieve slightly different goals in terms of how fast the baby grows.

"Because we found no differences in the size of the babies when they are born, it seems that the outcome of this conflict is a kind of equilibrium in which faster growth is offset by a shorter pregnancy."

Understanding how differences between species evolve and what combination of pressures and conflicts gives rise to certain physiological features can help us to appreciate issues as diverse as economics, farming and biodiversity.

Fact box

Mammal species
Type of placenta
Gestation length
Human Less folded (‘villous’) 9 months
Sheep Less folded (‘villous’) 5 months
Dog Highly folded (‘labyrinthine’) 2 months
Leopard Highly folded (‘labyrinthine’) 3 months

ENDS

Notes to editors

For interviews

Dr Capellini and Professor Barton are available for interviews on Monday 15, Tuesday 16 and Wednesday 17 November:

  • Dr Isabella Capellini, Research Associate, Department of Anthropology, Durham University +44 (0) 191 334 3298, e-mail isabella.capellini@dur.ac.uk. Please note that Dr Capellini can conduct interviews in fluent English and Italian
  • Professor Robert Barton, Department of Anthropology, Durham University +44 (0)191 334 1603, mobile +44 (0) 7507 564 773, e-mail r.a.barton@dur.ac.uk
  • Or, Dionne Hamil, Media Relations Office, Durham University on 00 44 (0) 191 334 6078, dionne.hamil@dur.ac.uk

Note for broadcasters

Durham University is 30 minutes away from BBC and independent TV and radio studios and Sky News have a fully-equipped studio based in Durham. Please note that our ISDN facility is currently under repair.

Images

Please note that we don't have any images available. For a simple illustration of the different placenta structures comparing a mouse placenta to that of a human, please see the web link below for reference (the copyright is not owned by Durham University). http://www.pnas.org/content/96/14/8138/F6.expansion.html

Source information

Placentation and maternal investment in mammals, Capellini, Venditti and Barton, published in The American Naturalist, 17 November 2010.

Electronic copies of the research paper are available from the Media Relations Office on the contact details above.

About Durham University

Durham University is a world top 100 university with a global reputation and performance in research and education. The most recent UK league tables place Durham in the top handful of British universities; we are ranked 4th in the country in the influential Complete University Guide. Based in North East England, we are a collegiate university based at two locations: Durham City and Stockton-on-Tees. Durham is England's third oldest university and has at its heart a UNESCO World Heritage Site, jointly owned with Durham Cathedral. www.durham.ac.uk

Durham is a member of the 1994 Group of 19 leading UK research-intensive universities: www.1994group.ac.uk

About BBSRC

BBSRC is the UK funding agency for research in the life sciences. Sponsored by Government, BBSRC annually invests around £450M in a wide range of research that makes a significant contribution to the quality of life in the UK  and beyond and supports a number of important industrial stakeholders, including the agriculture, food, chemical, healthcare and pharmaceutical sectors.

BBSRC provides institute strategic research grants to the following:

  • The Babraham Institute
  • Institute for Animal Health
  • Institute for Biological, Environmental and Rural Sciences (Aberystwyth University)
  • Institute of Food Research
  • John Innes Centre
  • The Genome Analysis Centre
  • The Roslin Institute (University of Edinburgh)
  • Rothamsted Research

The Institutes conduct long-term, mission-oriented research using specialist facilities. They have strong interactions with industry, Government departments and other end-users of their research.

External contact

Durham University Media Relations Office

tel: 0191 334 6075